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March 1967

A Method of Arterial Anastomosis Using Cyanoacrylate Tissue Adhesives

Author Affiliations

USA; USA; USAR; USA; Washington, DC
From the Division of Surgery, Walter Reed Army Institute of Research, Washington, DC. Drs. Pani and Leonard are with the US Army Medical Biomechanical Research Laboratory, Walter Reed Medical Center, Washington, DC.

Arch Surg. 1967;94(3):388-391. doi:10.1001/archsurg.1967.01330090082021

UNDER combat or mass casualty situations, vascular anastomosis is desired to be accomplished as rapidly as possible. Presently used suture techniques for end-to-end anastomosis are comparatively slow. Mechanical stapling techniques, although more rapid, require adequate space to insert the stapling device. Because of the limitations in these techniques, it was decided to attempt end-to-end anastomosis using a combination of suture and adhesive technique, using the α-alkyl-cyanoacrylate tissue adhesive monomers.

Materials and Methods  Thirty adult mongrel dogs weighing between 15 to 36 kg were used. All dogs were fed a normal laboratory diet and given water freely. The principles of laboratory animal care as promulgated by the National Society for Medical Research were observed. All operations were carried out under sterile conditions with the dogs under anesthesia induced by sodium pentobarbital administered intravenously under sterile conditions. N-butyl, isobutyl cyanoacrylate monomers, and the mixture of 95% heptyl and 5% methyl cyanoacrylate

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