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April 1967

Disseminated Melanoma: Biologic Behavior and Treatment

Author Affiliations

From the Department of Surgery, the University of Texas M. D. Anderson Hospital and Tumor Institute, Houston. Dr. Stehlin's present address is 834 Hermann Professional Building, Houston. Dr. Rufino is presently with the University of Mendoza, Mendoza, Argentina.

Arch Surg. 1967;94(4):495-501. doi:10.1001/archsurg.1967.01330100059009

HERETOFORE, studies of malignant melanoma, our own as well as those reported by others, have dealt chiefly with the clinical aspects of the disease in living patients. The present investigation was undertaken primarily in an attempt to evaluate the biologic behavior of fatal lesions. It was based upon the records of 222 patients who were treated at the M. D. Anderson Hospital, all of whom have died within the past several years, their course having been followed to the time of death.

A classification of melanoma according to the clinical and pathological evidence of its extent was developed in this hospital nine years ago (Table 1). This classification was used in staging the disease of the 222 patients. In every case, the presence of melanoma was established by histological findings. The primary tumors (stage 1) of some of the patients had been removed previously, and neither tumors nor slides were

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