EARLY IN the work with histamine, it was reported by Popielski1 and by Keeton and associates2 that this drug produced a gastric secretory response after section of the vagus nerves to the otherwise intact stomach. Ivy and Javois3 found that histamine would stimulate gastric secretion in a denervated gastric pouch and Klein4 reported that a similar response could be obtained from a transplanted gastric pouch that had been deprived of its muscular layers and myenteric plexus. In 1948, Oberhelman and Dragstedt5 noted that the gastric secretory response to a standard dose of histamine in dogs with a totally isolated stomach pouch was markedly reduced (44% to 77%) following bilateral vagotomy; and in 1961, Gelb and associates6 reported that the maximal histamine response in patients studied before and after vagotomy was reduced 59% to 93%. In 1964, Anderson and Olbe7 reported that vagal denervation
Schapiro H, Britt LG. Injection of 5% Phenol Into Submucosa of Denervated Gastric Pouch. Arch Surg. 1967;94(6):841–844. doi:10.1001/archsurg.1967.01330120095017
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