ONE OF the more interesting complications of plasma cell myeloma is the tendency to develop deposits of amyloid in various sites in the body. The frequency of this particular complication has been reported as 6% and 10% in two large series.1 The distribution of the amyloid may occur in a number of different patterns. Most often, it occurs exclusively within the myelomatous bone lesions and can be detected only by microscopic examination. Less commonly, large amyloid tumor masses may be seen in the muscles and connective tissues adjoining the bone lesions. Rarer still are the cases in which the amyloid deposits are predominantly extraskeletal. In these cases, the distribution is similar to that observed in primary systemic ("atypical") amyloidosis: there may be extensive infiltration of the tongue, mucous membranes, subcutaneous tissues, and occasionally certain of the visceral organs, but not of the myelomatous tumors in the bones.2
Lowell DM. Amyloid-Producing Plasmacytoma of the Pelvis: Case Report and Review of the Literature. Arch Surg. 1967;94(6):899–903. doi:10.1001/archsurg.1967.01330120153030
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