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July 1967

A Comparative Study of Naturally Occurring Canine Achalasia

Author Affiliations

From the Department of Surgery of the Graduate Hospital and the Graduate Division of the University of Pennsylvania School of Medicine, Philadelphia.

Arch Surg. 1967;95(1):83-88. doi:10.1001/archsurg.1967.01330130085017

A FORM of megaesophagus is found in the dog which resembles human achalasia and presents a unique opportunity for comparative study of this disease. Occasional cases of canine achalasia have been described in the veterinary literature, and as the availability of diagnostic procedures has increased, they have been found more frequently.1-5 Although radiologic similarities of achalasia in the two species have been noted,6,7 detailed study has not been carried out in the dog. Attempts have been made to produce achalasia in experimental animals by destruction of Auerbach's plexus,8,9 by cholinesterase inhibition,10 and by cervical vagotomy,11-13 but these have not been completely successful. If the naturally occurring disease process in the dog was found to be similar to the human disease, it could provide subjects for further investigation of the exact etiology. The object of the present study was to compare in detail the clinical and

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