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August 1967

The Effects of Congestion on Certain Liver Tissue Constituent Weights

Author Affiliations

From the Department of Surgery, Woman's Medical College of Pennsylvania, and the Department of Biostatistics, Jefferson Medical College, Philadelphia.

Arch Surg. 1967;95(2):217-219. doi:10.1001/archsurg.1967.01330140055012

AUGMENTATION of liver blood flow and volume has been regarded as a cause of liver regeneration. This contention has been based mainly on an observed increase in gross size and wet weight of the liver following constriction of the vena cava above and below the liver1 diversion of caval blood into the portal vein2 and portal arterialization experiments.3,4 Grindlay and Bollman concluded that "the liver needs to be well filled with venous blood for good regeneration to occur after partial hepatectomy and that... any procedure which will produce filling of the hepatic veins will favor regeneration of the liver."1 The increased experimental filling of the liver with blood may also produce weight changes as a result of congestion. Fisher et al believed that they could discount this possibility by measuring liver tissue dry weight and protein and by histologic examination.3 Recently, Thomson and Clarke evaluated

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