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October 1967

The Nature and Source of a Gastric Secretagogue: Observations From the Obstructed Portal Vein

Author Affiliations

From the Department of Surgery, University of Toronto.

Arch Surg. 1967;95(4):606-608. doi:10.1001/archsurg.1967.01330160076009

IT IS well known that gastric hypersecretion occurs in dogs with portacaval shunts.1-6 For the most part, this hypersecretion has been measured only after the dogs had stabilized for 30 days postoperatively. While constructing portacaval shunts in dogs with Heidenhain pouches, an immediate and marked pouch secretion was noted. This hypersecretion decreased over the following 24 hours and stabilized above preshunt levels. It seemed that a gastric secretagogue had accumulated in the obstructed portal vein while the shunt was being constructed; this "early" hypersecretion was investigated in dogs.


Confirming the Presence of a Secretagogue in Portal Blood.  —The portal vein was clamped for 30 minutes in 18 mongrel dogs anesthetized with pentobarbital (Nembutal). Major portal-systemic shunts were eliminated by clamping the vessels in the rectosigmoid area and at the cardiac end of the stomach. There were 50 cc of occluded portal blood, anticoagulated with 5 cc of sodium