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January 1968

Limiting Vascular Diameters in Various Organs: As Determined by Microspheres

Author Affiliations

New York
From the Department of Surgery, New York Medical College, and the Department of Physiology, Hunter College and the Laboratory Biometrics, Cornell University Medical College, New York.

Arch Surg. 1968;96(1):130-137. doi:10.1001/archsurg.1968.01330190132030

THE appearance of tumor cells in peripheral blood drawn from the antecubital vein in patients with various visceral cancers has been frequently reported.1-3 Depending upon the location of the primary tumor or its known secondaries, these cells would have traversed one or more organ vascular beds. Tumor cells are generally larger than the normal formed elements of the blood, a factor of possible importance in their arrest and subsequent development into metastases. Certain tissues and organs, including those of the distribution drained by the antecubital veins, are rarely the site of metastatic implant. It could be inferred from the clinical studies on antecubital vein blood that such tumor cells had either passed through or around the capillary beds of hand and forearm unimpeded and, hence, produced no metastases. There is no evidence, however, that other tumor cells had not entered these capillary beds, lodged, and become nonviable. Three possibilities

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