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March 1968

Lung Transplantation for Treatment of Pulmonary Hypertension in Dogs

Author Affiliations

Jackson, Miss
From the Department of Surgery, University of Mississippi Medical Center, Jackson.

Arch Surg. 1968;96(3):340-343. doi:10.1001/archsurg.1968.01330210018004

THE clinical applications of lung transplantation for the treatment of pulmonary insufficiency have been few.1-3 Although all recipients died within a period of one to three weeks, the transplanted lungs functioned reasonably well. Thus, it is of potential clinical importance to investigate the value of lung transplantation for the treatment of pulmonary hypertension. It is logical to assume that the substitution of a lung with normal pulmonary vascular resistance for one that is diseased should result in lowering of the pulmonary artery pressure and improvement of blood flow. The present study was undertaken to probe the validity of such a hypothesis.

Materials and Methods  Throughout the experiments adult mongrel dogs weighing 12 to 15 kg (26.4 to 33 lb) were used.

Group 1 

—Homotransplantation.  —Twenty-two dogs were lightly anesthetized with thiamylal anesthesia administered intravenously and a No.6 cardiac catheter was advanced into the right ventricular cavity through the external