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April 1968

Hepatic Artery Catheterization for Chemotherapy

Author Affiliations

From the Darling Memorial Center, Grace Hospital, Wayne State University College of Medicine, Detroit.

Arch Surg. 1968;96(4):683-692. doi:10.1001/archsurg.1968.01330220199029

CHEMOTHERAPY now is one of the accepted modes of treatment of metastatic tumor. Systemic administration of the chemotherapeutic agent has the distinct disadvantage of being toxic to normal tissues, particularly bone marrow, thus decidedly curtailing the concentration of drug that can be delivered to the tumor tissue. As first demonstrated by Klopp et al1 and later confirmed by others,2-10 in instances in which one organ is involved and the arterial supply can be isolated, the general deleterious effects of the drug can be reduced by delivering a high concentration to the organ over a fairly long period of time through its arterial blood supply, thus providing a constant bombardment of antimetabolites to the reproducing neoplastic cells. This method of therapy is termed "infusion," in contrast to "perfusion" in which the arterial and venous supply of the tumor-laden area, usually an extremity, is isolated from the general circulation and

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