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June 1968

A New Preparation for Gastric Secretory Studies in Dogs: Transplantation of the Autologous and Homologous Total Stomachs

Author Affiliations

From the Department of Surgery, University of Washington School of Medicine, Seattle. Dr. Odaka is a research fellow from the Second Surgical Department of Chiba University School of Medicine, Chiba, Japan. Dr. Nyhus is now at the University of Illinois, Chicago.

Arch Surg. 1968;96(6):902-908. doi:10.1001/archsurg.1968.01330240048011

PROGRESS with homotransplantation and isolated perfusion of stomach preparations has been made, but each method has its limitations. Prolonged survival of homografts is difficult to obtain. Furthermore, some drugs administered to prevent rejection interfere with normal gastric secretions. Isolated perfusion preparations are useful, but pose many technical problems.1

Although total, or partial stomach transplantation experiments and experiments of isolated gastric perfusions are not recent developments, the results have never been completely satisfactory.2,3 With the recent development of a technic which facilitates the anastomosis of small vessels, however, the number of stomach transplantation experiments undertaken has increased.4-9 In the study of homotransplantation of the distal half of the stomach by Thompson et al, 31 homografts receiving immunosuppressive drugs had an average survival of 12.7 days.8 Unfortunately, other investigators have not mentioned the average number of survival days in their reports. Experiments of isolated gastric perfusions have been

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