FAMILIAL or congenital polyposis is a disease of the colon and rectum characterized by multiple polyps which tend to become malignant. It is transmitted as a mendelian dominant characteristic and the heredofamilial malignant aspect has long been recognized.
In 1942 we reported in Archives1 a family of seven children, six of whom had polyposis of the colon. Now, a quarter of a century later, it seems appropriate to present a followup study of the same family.
The summary of the original paper noted that of the six children with familial polyposis of the colon, three were males and three were females. The youngest was 10 and the oldest was 30 years of age. Malignant changes had developed in the polyps of the two oldest, both males, and both had died. No symptoms were exhibited by any of the siblings before the age of 23. The father of the children