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August 1968

Thymic Neoplasm: A Surgical Enigma

Author Affiliations

From the Department of Surgery, Marquette School of Medicine, Milwaukee.

Arch Surg. 1968;97(2):230-238. doi:10.1001/archsurg.1968.01340020094011

TUMORS of the thymus gland have been the subject of continuing review and investigation1-7 with no appreciable improvement in the survival rate,8,9 particularly incident to the treatment of the malignant thymoma. Several consecutive patients in 1966 and 1967 prompted the authors to review their experiences in the treatment of this entity. Accordingly the records of all patients having roentgen evidence of an anterior mediastinal neoplasm were reviewed, yielding 29 patients whose lesions grossly appeared to take origin in the thymus gland and whose histopathologic appraisal does not contradict thymic origin (Table).

Associated disease syndromes are represented in this series by three patients with Cushinoid features, and a fourth with a thymoma having the epithelial histopathologic features, but without the clinical features of Cushing's syndrome.10-15 Additionally one patient had agenesis of erythrocytes,16-18 and one had had myocarditis19 as well as Cushing's syndrome. Only the patient with

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