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August 1968

Rejection of Skin Allografts by Healthy Humans: Relationship of Type of Rejection to Degree of Immunity

Author Affiliations

From the Surgical Research Laboratories, Edward J. Meyer Memorial Hospital, and the Department of Surgery, State University of New York at Buffalo.

Arch Surg. 1968;97(2):306-312. doi:10.1001/archsurg.1968.01340020170020

THIS article reports the clinical observations made while performing 149 experimental skin grafts on 51 healthy adult male volunteers. The group of 149 grafts was comprised of 144 allografts and five autografts.

The experiment was performed for the specific purpose of preparing a substantial number of human transplantation sera with which to study the normal serologic response of the human to skin allografts. Whether or not genetic disparity, as reflected in anthropologic variation, would influence the host's rejection of an allograft or would influence his serologic response to allografts was thought worthy of study.

Three principal observations were made: (1) Rejection occurred in three basic patterns. (2) The degree of host immunity which resulted from an allograft was better related to the pattern of graft rejection than it was to graft survival time. (3) Host immunity, when judged in this way, appeared to reflect histocompatibility differences between host and donor.

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