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October 1968

Acute Portal Hemoconcentration in Endotoxin Shock: Search for an Experimental Shock Model

Arch Surg. 1968;97(4):666-671. doi:10.1001/archsurg.1968.01340040162034

THE PURPOSE of this study is to elucidate the role of the spleen and portal hypertension in canine endotoxin shock, and the dynamic relationship between hematocrit values and pressure changes in the portal and systemic circulations following endotoxin administration. A median lethal dose (LD50) of endotoxin was used to enable a better assessment of the spectrum of pharmacologic and toxic effects of endotoxin.

Recent experimental efforts by Bounous et al have concerned the alteration of the canine experimental-shock model so that certain "artifacts" peculiar to the dog are removed, and a picture more closely resembling human shock is produced.1,2 By using the technique of pancreatic duct ligation, they were able to abolish hemorrhagic necrosis of the small intestinal mucosa which had characterized irreversible shock in the dog. The animal became resistant to a usually lethal episode of hemorrhagic shock and lived to develop lesions in the heart, lung,