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November 1968

Pulmonary Hemorrhage and Glomerulonephritis: Treatment of Two Cases by Bilateral Nephrectomy and Renal Transplantation

Author Affiliations

Gainesville, Fla
From the departments of surgery and medicine, University of Florida, College of Medicine, Gainesville. Dr. Shires is now at the Indiana University School of Medicine, Indianapolis.

Arch Surg. 1968;97(5):699-703. doi:10.1001/archsurg.1968.01340050039003

THE ASSOCIATION of hemoptysis and acute, rapidly fatal glomerulonephritis was described in 1919 by Goodpasture.1 The syndrome that bears his name is generally described in young male adults, with temporal concurrence of the renal and pulmonary symptoms. The majority of patients with this symptom complex have had a rapid and fatal progression of pulmonary and renal disease, and have died within a period of weeks or months.2,6 In isolated instances, prolonged survival has been reported,3-5 usually in association with high-dose adrenocorticoid therapy. One patient has survived with the aid of chronic hemodialysis.6

Report of Cases  Two patients, reported herein, had pulmonary hemorrhage, compromised pulmonary function and end-stage glomerulonephritis, and were managed with bilateral nephrectomy, chronic hemodialysis, and renal transplantation.Case 1.—A 21-year-old married housewife was admitted to a hospital on June 9, 1966, because of progressive weight loss, anorexia, and shortness of breath persisting for two

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