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November 1968

Aerosol Tissue Adhesive Spray: II. Fate of Freons and Their Acute Topical and Systemic Toxicity

Author Affiliations

Washington, DC
From the Division of Surgery (Drs. Matsumoto, Kovaric, and Hamit), Walter Reed Army Institute of Research, and the Biomechanical Research Laboratory (Dr. Pani), Walter Reed Army Medical Center, Washington, DC.

Arch Surg. 1968;97(5):727-735. doi:10.1001/archsurg.1968.01340050067008

AEROSOL tissue-adhesive spray developed at this Institute and by G. Barr Company, Niles, Ill, has been used successfully in Vietnam for hemostasis of otherwise fatal hemorrhage from liver and kidney wounds and for reinforcement of suture lines of vascular repairs and reconstructions.

The original method of application with a spray gun permitted delivery of a fine spray which formed a homogenous, uniform surface cover with a minimal volume of adhesive. However, the spray gun required meticulous and time-consuming cleaning with nitromethane after use, and a source of compressed gas (nitrogen, Freon, etc) to operate. Sterilization of this equipment was complicated, and the spray gun often malfunctioned—failed to spray (Fig 1). When Freon 12 instead of nitrogen was used as a source of compressed gas, the spray gun often discharged a large amount of liquid Freon on the tissue surface with a moderate pressure (70ψg) (Fig 2).

The basic difference between

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