THE GROSS physiological and morphological changes associated with the processes of wound formation and healing have been familiar phenomena during the entire period of recorded medical history. Undoubtedly prehistoric man also had good reasons to consider the subject. Nevertheless, the underlying processes which occur in the tissues at microscopic and submicroscopic levels continue to remain rather obscure. Most accidental injuries and practically all surgical incisions involve the connective tissues of the body which extend from the dermal layer of skin to include tendon, cartilage, periosteum, bone, and many other structures. An understanding of injury, wounding, and recovery must be based on the histology of the involved structures and on their normal physiology and adaptive responses. This applies not only to man, but also to all higher vertebrates, and must include all kinds of injuries to which they are exposed in nature. The ability of any species to survive would depend
Goldin EG, Joseph NR. Responses of Connective Tissue Ground Substance in Wound Healing. Arch Surg. 1968;97(5):753–763. doi:10.1001/archsurg.1968.01340050093013
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