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January 1969

Bioassay of the Serum in Zollinger-Ellison Syndrome: An Aid in Diagnosis and Prognosis

Author Affiliations

New York
From the Department of Surgery, Albert Einstein College of Medicine, New York.

Arch Surg. 1969;98(1):94-95. doi:10.1001/archsurg.1969.01340070112024

The use of biological tests to demonstrate a circulating secretagogue in Zollinger-Ellison (Z-E) syndrome patients has been reported by a number of authors using serum,1,2 gastric juice,1 or urine,3 in either dogs1,2 or rats.3 In the present case, we demonstrated a secretagogue in the serum preoperatively which disappeared after resection of a small islet cell tumor in the wall of the duodenum.

Report of a Case  A 55-year-old woman was perfectly well until the autumn of 1964 when she developed poorly defined upper abdominal pain and vomiting without diarrhea. Upper gastrointestinal x-ray studies revealed an active duodenal ulcer. Repeated serum calcium values were normal and there was no evidence of endocrine abnormality either in the patient or her family members. Antacid treatment resulted in partial relief of her pain, but in the spring of 1966 it again became severe. She was rehospitalized in September 1966