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January 1969

Inhibition of Pepsin Secretion by Acid in the Intestine

Author Affiliations

From the Harrison Department of Surgical Research (Drs. Copeland and Miller) and Department of Physiology (Dr. Smith), School of Medicine, University of Pennsylvania, Philadelphia. Dr. Smith is now at Cornell Medical Center, White Plains, NY.

Arch Surg. 1969;98(1):115-116. doi:10.1001/archsurg.1969.01340070133030

Following meal, pepsin output from a Heidenhain pouch (HP) is depressed below basal levels, while pepsin output from a Pavlov pouch (PP) increases markedly.1-3 A possible explanation of this difference may be that vagal denervation renders the peptic cells (chief cells) more vulnerable to intestinal inhibitory mechanisms activated by feeding. Fat in the intestine4,5 is known to inhibit pepsin secretion stimulated by a meat meal, histamine, or pilocarpine, but the effect is greater in PP than in HP.5 Acid in the intestine inhibits pepsin secretion from PP, but in the one HP studied, there was no certain effect. To examine the problem further, we diverted endogenous acid from the upper small bowel segments. The effect of the diversion of acid on pepsin secretion was evaluated in HP stimulated by varying doses of histamine.

Materials and Methods  In three healthy, male, mongrel dogs weighing 19 to 21.5 kg,