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March 1969

Oxyphenbutazone—Anti-inflammatory Agent—in Prevention of Peritoneal Adhesions

Author Affiliations

New Delhi
From the Department of Surgery, All India Institute of Medical Sciences, New Delhi.

Arch Surg. 1969;98(3):301-302. doi:10.1001/archsurg.1969.01340090077010

Postoperative peritoneal adhesions are one of the important causes of intestinal obstruction. Coletti and Bossart1 reported that in their series, intestinal adhesions were responsible for 90% of small bowel obstructions in the early postoperative period.

Numerous agents have been studied experimentally and clinically with regard to their usefulness in preventing the formation of intraperitoneal adhesions, but none, as yet, has proved consistently useful. Considering formation of peritoneal adhesions as an inflammatory process,2 an anti-inflammatory agent, oxyphenbutazone, has been used in this study to prevent it.

Materials and Methods  Forty rabbits were anesthetized with intravenously administered pentobarbital sodium. A laparotomy was carried out by a midline incision. The cecum and corresponding parietal peritoneum were scraped until the normal gloss was lost. The abdomen was closed in layers. The animals were studied in the following groups:Group A.—This group was subdivided into two. Group Al, the control group, consisted