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March 1969

Effect of Heterologous Serum Albumin on Liver Regeneration After Partial Hepatectomy

Author Affiliations

Los Angeles
From the Medical Service, Wadsworth Hospital, Veterans Administration Center, and the Department of Medicine, University of California School of Medicine, Los Angeles.

Arch Surg. 1969;98(3):369-371. doi:10.1001/archsurg.1969.01340090145028

Mamalian liver regenerates itself rapidly and completely following partial hepatectomy. At present, factors initiating and precisely regulating this process are not well understood.1 Glinos and Gey2 have suggested that one important regulatory factor is the level of serum albumin. They postulated that following partial hepatectomy the lowered level of serum albumin stimulates hepatic regeneration. Once the serum albumin level has been restored to its preoperative values, the stimulus for regeneration is removed and further growth ceases.

We attempted to test this hypothesis by giving large amounts of heterologous serum albumin to rats following partial hepatectomy. Our results show that large amounts of heterologous serum albumin following partial hepatectomy do not prevent regeneration of the liver.

Methods  Seventy-eight young adult white male Wistar rats were used. They were given commercial laboratory chow and water until the time of surgery. Pentobarbital sodium anesthesia and clean, but not sterile, surgical technique