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March 1969

Pancreatic Excretion of Erythromycin and Kanamycin: Comparison of Results Obtained via a Thomas Cannula and a Duodenopancreaticopyelostoma in Dogs

Author Affiliations

Rochester, Minn
From the sections of medicine (Drs. Bartholomew and Cain), microbiology (Dr. Karlson), and physiology (Dr. Wakim), Mayo Clinic and Mayo Foundation, and the Mayo Graduate School of Medicine (University of Minnesota) (Drs. Wyman and Aldrete), Rochester, Minn.

Arch Surg. 1969;98(3):381-383. doi:10.1001/archsurg.1969.01340090157033

Dainko and associates1,2 in 1963 described a surgical technique for the collection of total pancreatic secretion from dogs. A duodenopancreaticopyelostoma, similar to the choledocho-ureterostoma of Pearce and Eisenbrey3 and the cholecyst-nephrostoma of Kapsinow and colleagues,4 was prepared as a two-stage procedure. The first operation consisted of hemisectioning the urinary bladder, bisecting the urethra, and placing the catheters through the abdominal wall from each hemibladder. One week later, the right kidney was removed and the major pancreatic duct with a 2-cm cuff of duodenal wall was anastomosed to the remaining right renal pelvis. Thus, pancreatic fluid drained from the right hemibladder, and urine from the remaining kidney drained from the left hemibladder.

With this preparation Dainko and associates1,2 studied the pancreatic excretion of several antibiotics given intravenously including erythromycin, 250 mg (two dogs); kanamycin sulfate, 180 mg (two dogs); and colistin sulfate, 25 mg (three dogs).