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May 1969

Body Fluid Compartment Changes Following Large Volume Hemodilution: Comparison With and Without Heart Failure

Author Affiliations

From the Department of Surgery, Northwestern University Medical School, Chicago.

Arch Surg. 1969;98(5):602-606. doi:10.1001/archsurg.1969.01340110094009

The use of hemodilution for cardiopulmonary bypass has been an accepted technique for several years.1 There still exists considerable variation as to the type and amount of diluent used. Perfusates ranging from 5% dextrose and water to a complicated mathematical formula of mixtures including mannitol, low molecular weight dextran, serum albumin, steroids and antibiotics are used with success in various centers.2-4 Low volume prime is considered as essential by some, and others have shown large volume primes are safe and advantageous.5

Probably because of the variations of the amount and types of perfusate, some of the reported postoperative studies differ from ours. We elected to use lactated Ringer's solution as the diluent of choice, as suggested by Neville et al.6 It soon became obvious that those patients with no history of heart failure responded quite differently from those patients who were in congestive failure. An attempt