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May 1969

Effect of Cortisone and Corticotropin on Gastric Secretion and Peptic Ulceration in the Dog

Author Affiliations

From the Department of Surgery, University of Minnesota Hospitals and Veterans Administration Hospital, Minneapolis.

Arch Surg. 1969;98(5):640-644. doi:10.1001/archsurg.1969.01340110132017

That the etiology of peptic ulceration is not completely understood is confirmed by the intensity of research on this subject. Recently, there has been an increased emphasis on extragastric hormonal regulation of gastric secretion and its relationship to peptic ulceration. Many cases of endocrine abnormalities associated with peptic ulceration have been reported in the recent literature.1-3 Reports of ulcer formation, gastrointestinal hemorrhage, and gastroduodenal perforation during corticosteroid therapy have also appeared in the literature.4-6 These studies were performed to determine the following: (1) whether the administration of cortisone or corticotropin (ACTH) would enhance the secretory response of a vagally denervated pouch stimulated with histamine, (2) if there is a correlation between the dose of corticosteroids administered and pouch output, and (3) the effect of cortisone on histamine-induced ulceration in the dog.

Group 1  Methods.—Three adult mongrel dogs (10 to 15 kg [22 to 33 lb]) with previously