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May 1969

Granular Cell Myoblastoma of the Breast

Author Affiliations

From the Department of Pathology, Philadelphia General Hospital, Philadelphia. Dr. Vidyarthi is now at the University of North Dakota, Grand Forks.

Arch Surg. 1969;98(5):662-667. doi:10.1001/archsurg.1969.01340110154023

Granular cell myoblastoma, whether a misnomer or not, is a well-established entity of the medical literature. It occurs widely in the body. Its occurrence in the breast, though infrequent, is of great significance because of its clinical similarity to carcinoma. Only rarely a correct diagnosis is made clinically. Histological diagnosis is easy though diagnosis in a frozen section has been found to be simple by some1 and not so easy by others.2 Knowledge of the tumor and experience is thus important in avoiding errors in diagnosis.

About 6% of granular cell myoblastomas occur in the breast.3 A review of the literature has revealed 49 documented cases (Table). The present paper reports three additional cases which illustrate some of the difficulties involved in the diagnosis.

Report of Cases  Case 1.—A 55-year-old Negro laundress was admitted to the Philadelphia General Hospital on Feb 23, 1965, with a mass in the