It is now a well established fact that gastric hypersecretion follows massive intestinal resection.1 The cause for this hypersecretion of acid is unknown at present but may well be due to the absence of normal intestinal inhibitors of gastric secretion.2
The clinical use of reversed intestinal segments has rapidly evolved since 1951 when J. H. Hammer demonstrated that dogs could survive with reversal of the entire duodenum.3 Up to that time the conclusions of F. P. Mall and William Halsted4 in 1896 that reversed intestinal segments ultimately caused death in experimental animals through acute or chronic obstruction had remained unchallenged in the literature. In 1962, L. D. Gibson5 applied Hammer's suggestion6 clinically by reversing a 7.5-cm jejunal segment in a patient who had had a massive intestinal resection. The result was very encouraging and established the use of short reversed intestinal segments in people following
Kimura S, Dragstedt LR. Reversed Jejunal Segments and Gastric Hypersecretion. Arch Surg. 1969;98(6):713–715. doi:10.1001/archsurg.1969.01340120061007
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: