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September 1969

Effect of Antilymphocyte Serum on Mortality of Pseudomonas aeruginosa-Infected Rats

Author Affiliations

Jackson, Miss
From the Department of Surgery, University of Mississippi Medical Center, Jackson.

Arch Surg. 1969;99(3):382-384. doi:10.1001/archsurg.1969.01340150090017

TRANSPLANTATION of kidneys and other organs have become a common procedure in many medical centers. The use of immunosuppressants has made this possible, but it is clear that immunosuppression can create a serious defect in host resistance which often results in death of the transplant recipient because of infection.1 One of the newest and now widely used immunosuppressants is antilymphocyte serum (ALS). Though its exact mode of action is unknown, it is a powerful suppressant of the cellular response. Recent reports have shown ALS to act as an anti-inflammatory agent in response to certain chemicals2,3 and bacterial antigens.4 A definite increased susceptibility to a number of virus infections has been reported in animals treated with ALS leading to an increased morbidity and mortality.5 Little is known about the effect of ALS on host resistance to infections of bacterial origin. This report deals with this subject and