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December 1969

Survival of Heart Grafts: Extracorporeal Removal in a Functioning Stage and Those Obtained From Cadaver Donors

Author Affiliations

Charlotte, NC
From the Department of Cardiovascular and Thoracic Surgery, and the Heineman Research Laboratory, Charlotte Memorial Hospital, Charlotte, NC.

Arch Surg. 1969;99(6):750-752. doi:10.1001/archsurg.1969.01340180074015

The limited success of the first human transplantations certainly proved the fact that this procedure is a feasible one, but it has also demonstrated that several cardinal problems, including procurement and preservation, are far from being solved. Investigating the possibilities and limitations of heart "banking", we have studied the Starling preparation1 and its modifications2-4 (according to an oral communication from E. Matejicek, MD, June 1954) as a possible vehicle for organ transplantation. The "autoperfusing stabilized heart-lung preparation" was developed5-7 and was found to function without added mechanical circulatory support for prolonged periods; therefore, it appeared to be suitable to serve as a graft for transplantation. In this paper we present the results of our work with this preparation.

The Autoperfusing Stabilized Preparation  The preparation consists of the heart, aortic arch, and the lungs removed "en bloc" from the chest. A large plastic catheter is inserted into the

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