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January 1970

Response of Renal Allografts to Erythropoietic Stimuli: In the Presence of Immunosuppression

Author Affiliations

From the departments of urology and experimental surgery, Roswell Park Memorial Institute, and Regional Kidney Center, New York State Kidney Institute, New York State Department of Health, and the School of Medicine, State University of New York, Buffalo.

Arch Surg. 1970;100(1):20-23. doi:10.1001/archsurg.1970.01340190022007

Erythropoietin (ESF) is a hormone of renal origin active in the regulation of red cell production.1 Various factors or stimuli are known to result in ESF release. These include bleeding,2 hypoxic hypoxia exposure,3 exogenous androgen administration,4 or cobalt chloride treatment.5 Autotransplanted canine kidneys can respond to various erythropoietic stimuli as can normal intact kidneys.6

The present experiments were conducted to test further the response of animals with renal allografts, with and without various forms of immunosuppression to various erythropoietic stimuli.

Materials and Methods  Adult male and female mongrel dogs, in healthy condition, underwent bilateral nephrectomy and received a kidney from an unrelated donor. Postoperatively, animals with functioning grafts were either untreated or given yeast respiratory extract (PCO),7 50 mg/kg every other day; azathioprine (Imuran), 5 mg/kg daily, or azathioprine and PCO in similar but combined fashion. Routine biochemical and hematological preoperative and postoperative

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