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February 1970

Permanent Skin Homografting in Identical Twins

Arch Surg. 1970;100(2):126-128. doi:10.1001/archsurg.1970.01340200014002

The opportunity to successfully perform permanent cutaneous homografting in the treatment of the severely burned patient is a rarity. At the present time, it necessitates the involvement of monozygotic twins. The realization of its success demonstrates the tremendous breakthrough in burn therapy which could be accomplished by the solving of the antigen-antibody problems related to homotransplantation.

The first attempts at cutaneous homografting probably occurred in the late 1880's. Girdner1 and Schede2 in 1881 are generally accepted to be the first to have reported the attempted use of fresh cadaver grafts. Since that time it has been established that successful cutaneous homografting can occur between monozygotic twins and in patients with a gammaglobulinemia. It has also been reported in extremely rare instances of chance genetic similarity.

At the present time, there have been six reported instances of a monozygotic twin serving as a source of cutaneous graft in the treatment of