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February 1970

Motility Characteristics of Innervated and Denervated Antral Pouches in Dogs: Response to Antral Distention and Pentragastrin Administration

Author Affiliations

From the departments of surgery of University of Minnesota and Mount Sinai Hospital, and the Jay Phillips Research Laboratory, Minneapolis.

Arch Surg. 1970;100(2):195-200. doi:10.1001/archsurg.1970.01340200083018

Motility patterns in innervated canine antral pouches closely resemble those found in the main stomach. Denervated fundic (Heidenhain) and denervated antral pouches, however, have distinct and characteristic motility patterns which differ from those found in the main stomach or innervated antral pouches, a phenomenon well-documented by Robins and Boyd,1 Bercovitz2 and Quigley and Templeton.3

Sugawara,4 using a complete transection and reanastomosis technique at the junction of the antrum and body of the stomach to divide the intrinsic and extrinsic nerve plexuses, concluded that the postanastomotic (distal, denervated) segment manifested antiperistaltic activity, prolongation of spike discharge interval, and increased force of contraction. Motility remained unchanged in the preanastomotic segment.

All of the above observations suggest that the vagally denervated antral pouch has characteristic motility and may, in the absence of extrinsic parasympathetic innervation, respond independently of the remaining stomach to various stimuli. The following study was undertaken

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