Three cases of tumor of Brunner's glands, diagnosed within a few weeks of each other, prompted review of recent experience with this lesion at the Mayo Clinic. This experience is based on six cases exclusive of two cases reported previously, namely, one by Balfour and Henderson1 in 1929 and the other by Silverman and colleagues2 in 1961.
Wepfer3 in 1679 was the first to mention the presence of duodenal glands, but Brunn (Brunner)4 in 1688 first described them in detail.5 Embryologically, the glands develop during the sixth month when the cells at the base of the crypts of Lieberkühn extend into the submucosa. In maturity the glands achieve a compound tubular form, arranged in lobules, 0.5 to 1 mm in diameter. They generally are most numerous in the first portion of the duodenum, gradually decreasing in number distally. However, the number and distribution
ReMine WH, Brown PW, Gomes MMR, Harrison EG. Polypoid Hamartomas of Brunner's Glands: Report of Six Surgical Cases. Arch Surg. 1970;100(3):313–316. doi:10.1001/archsurg.1970.01340210089023
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