Recent work published by this laboratory in the subhuman primate has demonstrated that the primary cause of the decrease in mean systemic arterial pressure following a lethal injection of endotoxin is a decrease in venous return.1 However, a marked difference in response to endotoxin is observed in monkeys in contrast to dogs. In the former, a gradual fall in mean systemic arterial pressure is observed, and there is neither demonstrable pooling in the hepatosplanchnic bed nor loss of circulating blood to extravascular compartments.1-5
The cause of the decrease in venous return in the primate has not been determined. A previous study did not differentiate between a decrease in venous return due to peripheral pooling or failure of cardiac contractility.1 The cardiac output in some human patients shows a steady decline,6,7 although there is no evidence of primary cardiac failure in man6 or the nonhuman primate.
Hinshaw LB, Shanbour LL, Greenfield LJ, Coalson JJ. Mechanism of Decreased Venous Return: Subhuman Primate-Administered Endotoxin. Arch Surg. 1970;100(5):600–606. doi:10.1001/archsurg.1970.01340230066017
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