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August 1970

Donor Selection for Renal Transplantation Based on Genotypic Analysis of HL-A in a Family

Author Affiliations

From the departments of medicine (Drs. Hamby and Gantt), pathology (Dr. Smith), preventive medicine and community health (Dr. Lichter), and surgery (Drs. Jonasson and Nyhus), University of Illinois Medical Center, Chicago.

Arch Surg. 1970;101(2):219-225. doi:10.1001/archsurg.1970.01340260123020

Through studies of the distribution of HL-A antigens in a family and related donor selection on the basis of genotyping, excellent results have been achieved in cases of donor-recipient HL-A identity. Similar good results may be achieved in cases of donor-recipient monoallelic compatibility where the donor's nonshared allele is not associated with a major detectable HL-A antigen. In instances of monoallelic incompatibility where donor's nonshared allele is associated with a single detected HL-A antigen, the individual "strengths" of these antigens can be estimated on the basis of the clinical course of the recipient and studies of renal function and histology.

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