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August 1970

Tissue pH: A New Clinical Tool

Author Affiliations

From the Department of Surgery, Creighton University School of Medicine, and the Surgical Research Laboratories, Creighton Memorial St. Joseph's Hospital, Omaha.

Arch Surg. 1970;101(2):308-313. doi:10.1001/archsurg.1970.01340260212031

Serum pH may not tell the complete story in describing the body's response to disease processes. To provide information we have developed a technique for measuring tissue pH and have collected data from animals in which their physiology was altered by either hemorrhagic shock, lactic acid and bicarbonate infusion, or altered ventilation. We conclude that the tissue and serum pH vary in the same direction in the situations tested, but the magnitude of change depends upon the insult to the animal. We conclude there is sufficient evidence to show that tissue pH is a sensitive index to changes in tissue perfusion and might, therefore, be used clinically.