Most strains of Pseudomonas aeruginosa isolated from patients were lethal to burned mice but rats were relatively resistant and died of certain strains only. In burned rats, silver sulfadiazine (1.0%) applied daily beginning 24 hours postseeding with ratvirulent organisms resulted in 11.2% mortality compared to 12.5% mortality after treatment with mafenide. With certain strains, death occurred after treatment with mafenide but not with silver sulfadiazine. The effect of silver sulfadiazine was dose-related. In mice seeded with human-virulent strains (which were not lethal to rats) or strains lethal to both species the mortality was less than 20% with silver sulfadiazine and 83% with mafenide. Silver sulfadiazine proved effective in both rats and mice infected with virulent strains of Pseudomonas; mafenide was equally effective in rats but relatively ineffective in mice.
Fox CL, Sampath AC, Stanford JW. Virulence of Pseudomonas Infection in Burned Rats and Mice: Comparative Efficacy of Silver Sulfadiazine and Mafenide. Arch Surg. 1970;101(4):508–512. doi:10.1001/archsurg.1970.01340280060015
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