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November 1970

Effect of Gastrointestinal Hormones on Salivation in the Dog

Author Affiliations

Torrance and Los Angeles, Calif
From the departments of surgery and medicine, Harbor General Hospital, Torrance, Calif, and the University of California School of Medicine, Los Angeles. Dr. Clendinnen is now at Southmead Hospital, Bristol, England. Drs. Reeder and Thompson are now at the University of Texas Medical Branch, Galveston.

Arch Surg. 1970;101(5):596-598. doi:10.1001/archsurg.1970.01340290052011

The effect of synthetic human gastrin, pentagastrin, caerulein, pancreozymincholecystokinin (PZ-CCK), and secretin on salivary secretion was tested in dogs with salivary and denervated gastric fistulas. No changes were observed in salivary output. No effect on salivary volume or protein output was found using dosages of the agents which significantly altered gastric-acid output. We conclude that gastrin, PZ-CCK, and secretin are not involved in the physiological control of salivation.

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