Infusions of streptokinase (Streptase [Germany]) in 15 patients with chronic occlusions and stenosis of aorta, iliac, and femoral arteries resulted for some in less claudication, better treadmill performance, return of pulses, and improved appearance of arteriograms. Proximal short stenotic lesions respond more favorably than distal long occlusive ones. Complications of thrombolytic therapy did not preclude surgery where this was indicated.
Michael Hume, Victor Gurewich, Duncan P. Thomas, James B. Dealy. Streptokinase for Chronic Arterial Occlusive Disease. Arch Surg. 1970;101(6):653–657. doi:10.1001/archsurg.1970.01340300009003