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December 1970

Influence of Preparation and Immunosuppression Upon Longevity of Grafted Aortic Valves

Arch Surg. 1970;101(6):658-662. doi:10.1001/archsurg.1970.01340300014004

Aortic valves were transplanted from sheep and pigs into the descending thoracic aortas of nine groups of dogs. The valves were fresh, freeze-dried, or treated with propiolactone. Half the groups received azathioprine. The following conditions led to the best results: (1) transplantation of a minimum of aortic wall with the valve; (2) good initial alignment and movement of the cusps; (3) administration of azathioprine for eight weeks; and (4) support of the graft by a Dacron tube, preventing rupture and separating the graft from ingrowing host tissue.