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August 1971

Goodpasture's Syndrome: Treatment With Nephrectomy and Renal Transplantation

Author Affiliations

From the Department of Surgery, Veterans Administration Hospital and University of Colorado School of Medicine, Denver; and the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, Calif.

Arch Surg. 1971;103(2):283-289. doi:10.1001/archsurg.1971.01350080199031

Three young male patients developed acute glomerulonephritis and serious hemoptysis. All three had evidence of antiglomerular basement membrane (anti-GBM) antibodies in their serum and native kidneys. The pulmonary hemorrhages ceased after bilateral nephrectomy and splenectomy accompanied by irregular treatment with steroids and other immunosuppressants. Renal homotransplantation was successfully carried out from 95 to 162 days later, after circulating anti-GBM antibodies had disappeared. Two of the homografts were biopsied and the third was removed 20, 34, and 2 months posttransplantation, respectively, and contained little or no immunoglobulin. Therefore, Goodpasture's syndrome does not contraindicate renal transplantation under the stipulated conditions of staged therapy.