A comparison of the sensitivity of detection of metastatic bone disease by the bone scan and skeletal roentgenogram in 100 patients revealed a higher yield from the bone scan alone (86%) than from the roentgenogram alone (73%). In the tumor groups which frequently have osseous metastases (breast, prostate, and lung), the bone scan was greater than 95% accurate. Moreover, in patients with positive findings from both procedures, additional lesions were detected by the scan which were not demonstrated by the roentgenogram in 29%. A significant number of false negatives were encountered with both procedures when the entire group was examined. The greatest yield was obtained by employing both techniques.
Milner TH, Maynard CD, Cowan RJ. Evaluation of Strontium 85 Bone Scans and Roentgenograms in 100 Patients. Arch Surg. 1971;103(3):371–372. doi:https://doi.org/10.1001/archsurg.1971.01350090053011
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