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December 1971

Experimental Pancreatitis in Pigs

Author Affiliations

Ann Arbor, Mich
From the Section of General Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor.

Arch Surg. 1971;103(6):720-723. doi:10.1001/archsurg.1971.01350120084015

Unlike dog preparations, high pressure injection of bile and bile salt (taurocholate) does not cause immediate fatal pancreatitis in pigs. Bile salt does induce pseudocyst formation, pancreatic suppuration, septicemia, and azotemia in pigs. Pancreatic infusion of trypsin is also sublethal in pigs, but the combination of trypsin and bile salts at physiologic injection pressures produces a high mortality from acute hemorrhagic pancreatitis.