Colonic anastomoses were performed on two groups of 15 cats each. One group was preoperatively prepared with orally administered kanamycin sulfate and chloramphenicol; the other group was operated on without any preparation. The cats were reoperated upon 4, 6, and 11 days later. No complete sterility was achieved by orally administered chloramphenicol and kanamycin. This preparation facilitates appearance of bacterial strains resistant to the drugs used. A delay was found in the initial stage of the healing process in the prepared cats, evident in the fourth-day histological section. The delay was overcome on the 6th and 11th postoperative days. Staphylococcal proliferation in the cat colon was not found. After the orally administered antibiotic preparation, less peritoneal adhesions were found, whereas wound infections were more numerous and severe. On the basis of these results preoperative oral administration of antibiotics as an effective preparative method for colon surgery cannot be recommended.
Sternberg A, Kott I, Urca I, Lurie M. Preoperative Oral Antibiotic Treatment: Healing of Colonic Anastomoses in the Cat. Arch Surg. 1971;103(6):735–740. doi:https://doi.org/10.1001/archsurg.1971.01350120099018
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