[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
December 1971

An Autonomously Functioning Thyroid Nodule, Cancer, and Prior Radiation: Case Report and Hypothesis

Author Affiliations

Southfield, Mich
From Northfield Thyroid Laboratory, Southfield, Mich.

Arch Surg. 1971;103(6):759-761. doi:10.1001/archsurg.1971.01350120123024

The frequency with which the coexistence of thyroid cancer and autonomously functioning thyroid nodules (AFTN) is reported (both uncommon conditions) suggests that their association may not be entirely coincidental. Radiation therapy may predispose to the development of both benign and malignant thyroid nodules. Four of our 98 patients with AFTN gave histories of prior radiation therapy; one had coexistent thyroid cancer (the first described patient with AFTN and cancer after radiation therapy). It is suggested that a history of prior radiation therapy be diligently sought for all patients with AFTN, and, when obtained, further management planned with due regard for the possibility of coexistent cancer.