Hyperplastic cholecystosis designates a disease entity characterized by a functional abnormality of the gallbladder without specific anatomic changes. Six patients with the radiological diagnosis of hyperplastic cholecystosis have been treated with cholecystectomy. All patients reported complete relief from vomiting, pain, and food intolerance. Cholecystectomy, therefore, appears to be indicated in the symptomatic patient with the radiological findings of hyperplastic cholecystosis.