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May 1972

Oxygen Consumption and Systemic Hemodynamics During Low Perfusion Acidosis: Effect of Isoproterenol and Lactated Ringer's Solution

Author Affiliations

Loma Linda, Calif
From the Department of Surgery, Surgical Research Laboratory, Loma Linda (Calif) University School of Medicine.

Arch Surg. 1972;104(5):692-695. doi:10.1001/archsurg.1972.04180050066015

Isoproterenol hydrochloride and lactated Ringer's solution were employed in the treatment of low perfusion acidosis produced by acute blood volume reduction in 27 dogs. Their relative effectiveness was determined by measuring oxygen consumption, cardiac rate and output, and blood pressure. Neither isoproterenol nor lactated Ringer's solution produced significant improvement in either cardiac function or oxygen uptake. Significant improvement did, however, result when lactated Ringer's solution and isoproterenol were used in combination.

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