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August 1972

Intestinal Ischemia and Some Organic Substances in Serum and Abdominal Fluid

Author Affiliations

Newark, NJ
From the Department of Surgery, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Martland Hospital, Newark.

Arch Surg. 1972;105(2):151-157. doi:10.1001/archsurg.1972.04180080007002

Serum and abdominal fluid concentrations of 12 substances were evaluated in groups of dogs who had ischemic obstruction, simple intestinal obstruction, or sham operation performed. One group was used as a control model. No significant changes were found in serum. In abdominal fluid, the following changes were noted: lactic dehydrogenase increased from 18.3 to 136.9 units/ml (simple obstruction group), and from 18.2 to 228.7 units/ml (ischemic obstruction). Aldolase rose from 4.13 to 13.62 units/ml (simple obstruction), and from 1.99 to 16.28 units/ml (ischemic obstruction). Intestinal alkaline phosphatase rose from 0.11 to 0.89 units/ml. There was a significant increase in both the control group and the simple obstruction group after 3½ hours. Lactic acid rose from 0.226μM/ml to 1.636μM in the ischemic group.

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