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August 1972

Experimental Pulmonary Fat Embolism: Effects on Pulmonary Function by Reserpine Pretreatment

Author Affiliations

From the Department of Surgery, State University of New York, and the Surgical Research Laboratory and Department of Pathology of the E.J. Meyer Memorial Hospital, Buffalo.

Arch Surg. 1972;105(2):275-279. doi:10.1001/archsurg.1972.04180080127021

Two groups of eight dogs each received injections of olive oil (1.5 ml/kg) after control measurements were taken. One group was pretreated with reserpine (0.25 mg/kg) for two days. Both groups had the same initial changes in hemodynamics and pulmonary function. However, by three to five hours the reserpine-treated group clearly had less arterial hypoxia (oxygen pressure [PAO2] 77.1 vs 55 mm Hg) on the basis of a smaller calculated pulmonary shunt (9.92% vs 14.9%), and on the basis of a higher cardiac output (63% vs 55% of initial value).

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