Twelve Heidenhain pouch dogs were examined for pancreatic and hepatic effects on humoral gastric secretion. In three dogs pancreatin and methionine given orally did not change pouch output of acid. Total pancreatectomy was performed in the remaining nine dogs. In three dogs pancreatin and methionine were given immediately after surgery to prevent fatty metamorphosis, and gastric secretion steadily rose to 150% above control levels at 11 weeks.
The remaining six dogs were allowed to develop a fatty liver for eight weeks before treatment with pancreatin and methionine was initiated. In three the liver function returned to normal, but there was no alteration of the steady rise in pouch secretion to 376% above control levels at 16 weeks. In the other three dogs the liver function did not return to normal and their average pouch secretion levels rose steadily to 296% above control levels at 16 weeks.